Frank W Sellke Selected Research

Fibrosis (Cirrhosis)

1/2023	Canagliflozin Improves Myocardial Perfusion, Fibrosis, and Function in a Swine Model of Chronic Myocardial Ischemia.
12/2022	Extracellular vesicles improve diastolic function and substructure in normal and high-fat diet models of chronic myocardial ischemia.
1/2022	Calpain inhibition decreases myocardial fibrosis in chronically ischemic hypercholesterolemic swine.
8/2017	Effects of Alcohol on Postoperative Adhesion Formation in Ischemic Myocardium and Pericardium.
11/2014	Metformin mitigates apoptosis in ischemic myocardium.
10/2013	Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia.
9/2012	Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine.
1/2012	Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia.
10/2011	Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Frank W Sellke Research Topics

Disease

83	Myocardial Ischemia (Ischemic Heart Diseases) 03/2024 - 02/2002
49	Ischemia 11/2023 - 07/2002
28	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2023 - 07/2010
25	Coronary Artery Disease (Coronary Atherosclerosis) 09/2023 - 02/2003
24	Hypercholesterolemia 01/2022 - 08/2004
16	Reperfusion Injury 09/2023 - 02/2002
14	Hypoxia (Hypoxemia) 11/2023 - 12/2003
12	Inflammation (Inflammations) 11/2023 - 01/2007
11	Infarction (Infarctions) 01/2023 - 02/2002
11	Hemorrhage 01/2022 - 01/2007
10	Stroke (Strokes) 01/2023 - 12/2008
10	Coronary Disease (Coronary Heart Disease) 05/2012 - 02/2003
9	Hypertension (High Blood Pressure) 05/2024 - 01/2003
9	Cardiovascular Diseases (Cardiovascular Disease) 02/2024 - 01/2006
9	Fibrosis (Cirrhosis) 01/2023 - 10/2011
8	Myocardial Infarction 01/2023 - 02/2002
7	Atrial Fibrillation 08/2021 - 10/2007
5	Diabetes Mellitus 11/2022 - 09/2004
5	Myocardial Reperfusion Injury 01/2016 - 10/2002
5	B-Cell Lymphoma (Lymphoma, B Cell) 09/2013 - 03/2009
4	Necrosis 03/2014 - 05/2008
3	Insulin Resistance 11/2023 - 07/2010
3	Wound Infection (Wound Infections) 11/2023 - 09/2005
3	Aortic Valve Stenosis (Aortic Stenosis) 01/2021 - 08/2014
3	Obesity 01/2020 - 08/2011
3	Atherosclerosis 11/2017 - 05/2008
3	Renal Insufficiency (Renal Failure) 08/2014 - 05/2005
3	Thrombosis (Thrombus) 03/2011 - 05/2005
2	Spasm (Spasms) 05/2024 - 11/2004
2	Endocarditis 02/2022 - 12/2018
2	COVID-19 09/2021 - 01/2021
2	Chronic Renal Insufficiency 01/2020 - 03/2010
2	Peripheral Vascular Diseases (Peripheral Vascular Disease) 01/2020 - 03/2010
2	Pulmonary Atelectasis 01/2019 - 05/2018

Drug/Important Bio-Agent (IBA)

50	ameroidIBA 03/2024 - 03/2003
32	Proteins (Proteins, Gene)FDA Link 05/2024 - 07/2002
14	CholesterolIBA 01/2023 - 04/2008
14	ResveratrolIBA 01/2016 - 06/2009
12	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2014 - 03/2003
12	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2012 - 02/2003
10	Glucose (Dextrose)FDA LinkGeneric 06/2024 - 09/2005
10	Insulin (Novolin)FDA Link 11/2017 - 09/2005
8	Arginine (L-Arginine)FDA Link 11/2021 - 04/2004
8	Atorvastatin (Lipitor)FDA Link 02/2015 - 07/2006
7	CalpainIBA 11/2023 - 08/2015
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2022 - 10/2002
7	CytokinesIBA 11/2017 - 03/2004
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2015 - 07/2006
6	ChloridesIBA 12/2010 - 06/2009
6	Thrombin FDA Link 09/2010 - 05/2005
5	CanagliflozinIBA 03/2024 - 01/2023
5	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2023 - 02/2006
5	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2021 - 04/2010
5	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 04/2008 - 07/2002
5	Aprotinin (Trasylol)FDA Link 01/2007 - 10/2004
4	AntioxidantsIBA 01/2023 - 07/2013
4	Adenosine Monophosphate (AMP)IBA 01/2023 - 07/2009
4	CollagenIBA 01/2022 - 11/2014
4	Caspase 3 (Caspase-3)IBA 01/2018 - 04/2004
4	Dabigatran FDA Link 05/2017 - 08/2015
4	idarucizumabIBA 05/2017 - 08/2015
4	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2015 - 05/2008
4	Neuropeptide YIBA 10/2013 - 12/2010
4	rusalatide acetate (Chrysalin)IBA 09/2010 - 03/2009
3	SodiumIBA 06/2024 - 01/2023
3	Serotonin (5 Hydroxytryptamine)IBA 05/2024 - 01/2012
3	EnzymesIBA 01/2023 - 05/2005
3	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 12/2022 - 11/2010
3	Adenosine (Adenocard)FDA LinkGeneric 11/2022 - 09/2012
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 10/2006
3	Mitogen-Activated Protein KinasesIBA 12/2018 - 11/2003
3	Glycogen Synthase KinasesIBA 01/2018 - 12/2016
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2017 - 11/2010
3	AnticoagulantsIBA 05/2017 - 08/2015
3	Oxygen (Dioxygen)IBA 01/2016 - 10/2002
3	Metformin (Glucophage)FDA LinkGeneric 11/2014 - 03/2012
3	Poly Adenosine Diphosphate RiboseIBA 09/2013 - 02/2002
2	Sodium-Glucose Transporter 2 InhibitorsIBA 03/2024 - 01/2024
2	Sitagliptin Phosphate (Januvia)FDA Link 03/2024 - 06/2023
2	Thromboxane A2 (A2, Thromboxane)IBA 02/2024 - 12/2022
2	Protein Kinase CIBA 09/2023 - 09/2013
2	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2023 - 01/2003
2	Protein Kinases (Protein Kinase)IBA 01/2023 - 06/2014
2	CalciumIBA 11/2022 - 12/2020
2	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 05/2005

Therapy/Procedure

37	Therapeutics 03/2024 - 02/2003
20	Cardiopulmonary Bypass (Heart-Lung Bypass) 05/2024 - 08/2003
10	Induced Heart Arrest (Cardioplegia) 01/2023 - 08/2003
9	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/2022 - 09/2004
4	Transcatheter Aortic Valve Replacement 01/2021 - 08/2014
4	Stents 06/2014 - 03/2011
4	Anesthesia 01/2010 - 12/2008
4	Resuscitation 01/2010 - 12/2008
4	Critical Care (Surgical Intensive Care) 01/2010 - 12/2008
3	Length of Stay 01/2019 - 01/2019
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2011 - 04/2008
2	Ligation 01/2023 - 08/2003
2	Intravenous Injections 01/2023 - 01/2020
2	Percutaneous Coronary Intervention 01/2022 - 05/2016
2	Chest Tubes (Chest Tube) 01/2022 - 05/2014